The T/t locus was a major focus of study by mouse geneticists during the 20th century. In the 70s, as the study of cell surface antigens controlling transplantation antigens was taking off, several laboratories hypothesized that alleles of this locus would control cell surface antigens important for embryonic development. One such antigen, the embryonal carcinoma F9 antigen was said to be an example. Other antigens were described on sperm and embryos that were said to be controlled by alleles at the (...) T/t complex. These findings were later found to be false. The history of the findings and their refutation is described. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:348 BOOK REVIEWS to God's commandments is "the way and condition of salvation" (VS # 12). Now obedience to the commandments entails, in addition to a good motivation or a willingness to strive, the conformity of an action's object to the specifying content of the commandment. What is the significance of a commandment to honor one's father and mother, if it does not specify actions? The commandments of God (...) specify what kinds of action are, or are not, in conformity with the true good of man. In his analysis of the moral act, the Pope holds that the object of the act is "the primary and decisive element for moral judgment" (VS # 79). Actions which by the nature of their object are unable to be ordered to man's true end can never be "good" actions. Further, he notes that acts, even individual acts, are determinative of the goodness or badness of the person. These points are summarized nicely in the following passage: Activity is morally good when it attests to and expresses the voluntary ordering of the person to his ultimate end and the conformity of a concrete action with the human good as it is acknowledged in its truth by reason. If the object of the concrete action is not in harmony with the true good of the person, the choice of that action makes our will and ourselves morally evil, thus putting us in conflict with our ultimate end, the supreme good, God himself (VS # 72). I believe that Keenan's study commendably highlights the freedom of the will in the order of exercise, and its power to exercise dominion over the intellect in the order of specification. Keenan also insightfully emphasizes the central role of the love of God as the root of our striving to live well. Yet any willing can only be consequent to some knowing. Further, the willingness to strive and be determined, if it is good, is a willingness to be determined, or specified, by the true good known by reason and faith. This willingness, which is a crucial element in moral goodness, must be completed by actions in conformity with the true good. Human goodness is in freely, and lovingly, living out the truth of human nature and its end. The Catholic University of America Washington, D.C. JOHN A. D. CUDDEBACK Moral Absolutes: Tradition, Revision, and Truth. By JOHN FINNIS. Washington, D.C.: The Catholic University of America Press, 1991. Pp. 113. $24.95 (cloth), $9.95 (paper). Not long after his conversion to Roman Catholicism, Alasdair MacIntyre told a group of Catholic bishops: " As a matter of autobio- BOOK REVIEWS 349 graphical fact, I came to the conclusion that there were exceptionless and binding [moral] norms prior to and quite independently of any faith in Divine Revelation." Within the Church Macintyre entered, however, there existed, and exists, widespread doubt and confusion about "moral absolutes" or " exceptionless moral norms." Certain eminent Catholic moral theologians today dissent from Pope John Paul's teaching that " there exist acts which per se and in themselves, independently of circumstances, are always seriously wrong by reason of their object." In the face of this dissent, John Finnis has produced a powerful philosophical and theological defense of the papal teaching. Moral Absolutes presents the 1988 Michael J. McGivney Lectures which Finnis delivered at the John Paul II Institute for Studies on Marriage and the Family. The hook consists of four chapters: "Foundations," "Clarifications," "Christian Witness," and "Challenge and Response." Like Macintyre, Finnis maintains that the authority of scripture and tradition supplement reason's grasp of certain specific types of act as intrinsically wicked and, therefore, never to he performed. Although his goal is to vindicate the proposition that there are moral absolutes, rather than to say which, or even how many, moral norms qualify as " exceptionless " (and therefore as, in the relevant sense of the term, " absolute "), his examples include norms against abortion (and, more generally, the direct killing of innocent human beings), adultery, fornication, contraception, homosexual sex, blasphemy, and disclaimer of the faith. As Finnis observes, the Church's tradition of proclaiming these norms and their absoluteness is "massively solid." Against certain neoscholastic... (shrink)

Contemporary liberal thinkers commonly suppose that there is something in principle unjust about the legal prohibition of putatively victimless crimes. Here Robert P. George defends the traditional justification of morals legislation against criticisms advanced by leading liberal theorists. He argues that such legislation can play a legitimate role in maintaining a moral environment conducive to virtue and inhospitable to at least some forms of vice. Among the liberal critics of morals legislation whose views George considers are Ronald Dworkin, Jeremy (...) Waldron, David A.J. Richards, and Joseph Raz. He also considers the influential modern justification for morals legislation offered by Patrick Devlin as an alternative to the traditional approach. George closes with a sketch of a "pluralistic perfectionist" theory of civil liberties and public morality, showing that it is fully compatible with a defense of morals legislation. Making Men Moral will interest legal scholars and political theorists as well as theologians and philosophers focusing on questions of social justice and political morality. (shrink)

"Crease’s brilliantly exploited theatrical analogy places scientific theorizing back into the wider context of experimental inquiry." —Robert C. Scharff Crease attacks the "mystical" account of experimentation embraced by the positivist and Kantian varieties of philosophy of science, according to which experimentation takes a backseat to theory.

In this book it is argued that this picture of Feyerabend is false.

"Public reason" is one of the central concepts in modern liberal political theory. As articulated by John Rawls, it presents a way to overcome the difficulties created by intractable differences among citizens' religious and moral beliefs by strictly confining the place of such convictions in the public sphere. Identifying this conception as a key point of conflict, this book presents a debate among contemporary natural law and liberal political theorists on the definition and validity of the idea of public reason. (...) Its distinguished contributors examine the consequences of interpreting public reason more broadly as "right reason," according to natural law theory, versus understanding it in the narrower sense in which Rawls intended. They test public reason by examining its implications for current issues, confronting the questions of abortion and slavery and matters relating to citizenship. This energetic exchange advances our understanding of both Rawls's contribution to political philosophy and the lasting relevance of natural law. It provides new insights into crucial issues facing society today as it points to new ways of thinking about political theory and practice. (shrink)

QBism is an interpretation of quantum mechanics that posits quantum probabilities as subjective Bayesian probabilities, whence its name. By avoiding experientially unfulfilled speculations about what exists prior to measurement, QBism seems to make a close encounter with the phenomenological method. What follows is an interview with QBism’s founder and principal champion, the physicist Christopher Fuchs.

Natural law theory is enjoying a revival of interest in a variety of scholarly disciplines including law, philosophy, political science, and theology and religious studies. This volume presents twelve original essays by leading natural law theorists and their critics. The contributors discuss natural law theories of morality, law and legal reasoning, politics, and the rule of law. Readers get a clear sense of the wide diversity of viewpoints represented among contemporary theorists, and an opportunity to evaluate the arguments and counterarguments (...) exchanged in the current debates between natural law theorists and their critics. Contributors include Hadley Arkes, Joseph M. Boyle, Jr., John Finnis, Robert P. George, Russell Hittinger, Neil MacCormick, Michael Moore, Jeffrey Stout, Joseph Raz, Jeremy Waldron, Lloyd Weinreb, and Ernest Weinrib. (shrink)

: The purpose of this paper and its sister paper (Farrell and Hooker, b) is to present, evaluate and elaborate a proposed new model for the process of scientific development: self-directed anticipative learning (SDAL). The vehicle for its evaluation is a new analysis of a well-known historical episode: the development of ape-language research. In this first paper we outline five prominent features of SDAL that will need to be realized in applying SDAL to science: 1) interactive exploration of possibility space; (...) 2) self-directedness; 3) localization of success and error; 4) Synergistic increase in learning capacity; and 5) continuity of SDAL process across scientific change. In this paper we examine the first three features of SDAL in relation to the early history of ape-language research. We show that this history is readily explicated as a self-directed, ever-finer, delineation of possibility space that enables the localization of both success and error. Paper II examines the last two features against this history. (shrink)

Our understanding of the sense of taste is largely based on research designed and interpreted in terms of the traditional four tastes: sweet, sour, salty, and bitter, and now a few more. This concept of basic tastes has no rational definition to test, and thus it has not been tested. As a demonstration, a preliminary attempt to test one common but arbitrary psychophysical definition of basic tastes is included in this article; that the basic tastes are unique in being able (...) to account for other tastes. This definition was falsified in that other stimuli do about as well as the basic words and stimuli. To the extent that this finding might show analogies with other studies of receptor, neural, and psychophysical phenomena, the validity of the century-long literature of the science of taste based on a few is called into question. The possible origins, meaning, and influence of this concept are discussed. Tests of the model with control studies are suggested in all areas of taste related to basic tastes. As a stronger alternative to the basic tradition, the advantages of the across-fiber pattern model are discussed; it is based on a rational data-based hypothesis, and has survived attempts at falsification. Such has found broad acceptance in many neural systems. (shrink)

Research on social influences often distinguishes between social and quality incentives to ascribe meaning to the value that popularity conveys. This study examines the neural correlates of those incentives through which popularity influences preferences. This research reports an functional magnetic resonance imaging experiment and a behavioral task in which respondents evaluated popular products with three focus perspectives; unspecified focus, focus on social aspects, and focus on quality. The results show that value derived with a social focus reflects inferences of approval (...) and reward value, and positively affects preferences. Value derived with a quality focus reflects inferences of quality and negatively affects preferences. This study provides evidence of two distinct inferential routes on both a neurological level, represented by different regions in the brain, and a behavioral level. These results provide the first evidence that a single popularity cue can in different ways influence the value derived from product popularity. (shrink)

J. L. Schellenberg claims that the weakness of evidence for God’s existence is not merely a sign that God is hidden, “it is a revelation that God does not exist.” In Divine Hiddenness: New Essays, Michael J. Murray provides a “soul-making” defense of God’s hiddenness, arguing that if God were not hidden, then some of us would lose what many theists deem a (very) good thing: the ability to develop morally significant characters. In this paper, I argue that Murray’s soul-making (...) defense not only fails to defend God’s hiddenness, it produces (ironically) an argument for the nonexistence of God. (shrink)

There is no question, of course, that music is a temporal art. Stravinsky, noting that it is inconceivable apart from the elements of sound and time, classifies it quite simply as "a certain organization in time, a chrononomy."1 His definition stands as part of a long and honored tradition that encompasses such diverse figures as Racine, Lessing, and Schopenhauer. Schopenhauer, putting the case in its strongest terms, remarks that music is "perceived solely in and through time, to the complete exclusion (...) of space," thus making explicit the opposition between time and space and ruling out the latter as a possible area for legitimate musical experience. Yet anyone familiar with the philosophical and theoretical literature dealing with music must be struck by the persistence with which spatial terminology and categories appear. Indeed, it would seem to be impossible to talk about music at all without invoking spatial notions of one kind or another. Thus in discussing even the most elementary aspects of pitch organization—and among the musical elements, only pitch, we should remember, is uniquely musical—one finds it necessary to rely upon such spatially oriented oppositions as "up and down," "high and low," "small and large" , and so on. Space, then, pace Schopenhauer, apparently forms an inseparable part of the musical experience. · 1. Igor Stravinsky, Poetics of Music in the Form of Six Lessons, trans, Arthur Knodel and Ingolf Dahl , p. 28. Robert P. Morgan is active as both a music composer and theorist. A professor of music at the University of Chicago, he is currently composing a concerto for flute, oboe, and string orchestra to be performed at Swarthmore College. His previous contribution to Critical Inquiry, "On the Analysis of Recent Music," appeared in the Autumn 1977 issue. Anthony Gilbert responds to the current essay in "Musical Space: A Composer's View". (shrink)

J. L. Schellenberg claims that the weakness of evidence for God’s existence is not merely a sign that God is hidden, “it is a revelation that God does not exist.” In Divine Hiddenness : New Essays, Michael J. Murray provides a “soul-making” defense of God’s hiddenness, arguing that if God were not hidden, then some of us would lose what many theists deem a good thing: the ability to develop morally significant characters. In this paper, I argue that Murray’s soul-making (...) defense not only fails to defend God’s hiddenness, it produces an argument for the nonexistence of God. (shrink)

This monograph is designed to provide an introduction to the principal areas of tense logic. Many of the developments in this ever-growing field have been intentionally excluded to fulfill this aim. Length also dictated a choice between the alternative notations of A. N. Prior and Nicholas Rescher - two pioneers of the subject. I choose Prior's because of the syntactical parallels with the language it symbolizes and its close ties with other branches of logi cal theory, especially modal logic. The (...) first chapter presents a wider view of the material than later chapters. Several lines of development are consequently not followed through the remainder of the book, most notably metric systems. Although it is import ant to recognize that the unadorned Prior-symbolism can be enriched in vari ous ways it is an advanced subject as to how to actually carry off these enrichments. Readers desiring more information are referred to the appropri ate literature. Specialists will notice that only the first of several quantifi cational versions of tense logic is proven complete in the final chapter. Again constraints of space are partly to blame. The proof for the 'star' systems is wildly complex and at the time of this writing is not yet ready for publi cation. (shrink)

: The purpose of this paper and its sister paper I (Farrell and Hooker, a) is to present, evaluate and elaborate a proposed new model for the process of scientific development: self-directed anticipative learning. The vehicle for its evaluation is a new analysis of a well-known historical episode: the development of ape language research. Paper I examined the basic features of SDAL in relation to the early history of ape-language research. In this second paper we examine the reconceptualization of ape-language (...) research following what many conceived to be Terrace's refutation of ape-language. We show that the apparent 'revolution' in our understanding of ape linguistic capacities was not based upon 'revolutionary' research different in kind from 'normal' research. The same processes of self-directed interactive exploration of possibility space, that enables a homing-in upon both error and success, is present in all phases of productive science. Moreover, conceiving science as an SDAL process explains how scientists learn how to learn about their research domain. (shrink)

Joseph Newhard (2017) argues that a libertarian anarchist society would be at a serious military disadvantage if it extended the nonaggression principle to include potential foreign invaders. He goes so far as to recommend cultivating the ability to launch a nuclear attack on foreign cities. In contrast, I argue that the free society would derive its strength from a total commitment to property rights and the protection of innocent life. Both theory and history suggest that a free society would be (...) capable of defending itself, and indeed that it would probably use other means to avoid military conflict altogether. (shrink)

Selected by CHOICE as an Outstanding Academic Book for 1995.

This article is a case study that describes the natural and human history of the gaze heuristic. The gaze heuristic is an interception heuristic that utilizes a single input repeatedly as a task is performed. Its architecture, advantages, and limitations are described in detail. A history of the gaze heuristic is then presented. In natural history, the gaze heuristic is the only known technique used by predators to intercept prey. In human history the gaze heuristic was discovered accidentally by Royal (...) Air Force fighter command just prior to World War II. As it was never discovered by the Luftwaffe, the technique conferred a decisive advantage upon the RAF throughout the war. After the end of the war in America, German technology was combined with the British heuristic to create the Sidewinder AIM9 missile, the most successful autonomous weapon ever built. There are no plans to withdraw it or replace its guiding gaze heuristic. The case study demonstrates that the gaze heuristic is a specific heuristic type that takes a single best input at the best time. Its use is an adaptively rational response to specific, rapidly evolving decision environments that has allowed those animals/humans/machines who use it to survive, prosper, and multiply relative to those who do not. (shrink)

Much controversy surrounds Schenker's mature theory and its attempt to explain musical pitch motion. Becoming Heinrich Schenker brings a new perspective to Schenker's theoretical work, showing that ideas characteristic of his mature theory, although in many respects fundamentally different, developed logically out of his earlier ideas. Robert P. Morgan provides an introduction to Schenker's mature theory and traces its development through all of his major publications, considering each in detail and with numerous music examples. Morgan also explores the relationship (...) between Schenker's theory and his troubled ideology, which crucially influenced the evolution of his ideas and was heavily dependent upon both the empirical and idealist strains of contemporary German philosophical thought. Relying where possible on quotations from Schenker's own words, this book offers a balanced approach to his theory and a unique overview of this central music figure, generally considered to be the most prominent music theorist of the twentieth century. (shrink)

We present evidence disputing the hypothesis that memories are processed or consolidated in REM sleep. A review of REM deprivation (REMD) studies in animals shows these reports to be about equally divided in showing that REMD does, or does not, disrupt learning/memory. The studies supporting a relationship between REM sleep and memory have been strongly criticized for the confounding effects of very stressful REM deprivation techniques. The three major classes of antidepressant drugs, monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), and (...) selective serotonin reuptake inhibitors (SSRIs), profoundly suppress REM sleep. The MAOIs virtually abolish REM sleep, and the TCAs and SSRIs have been shown to produce immediate (40–85%) and sustained (30–50%) reductions in REM sleep. Despite marked suppression of REM sleep, these classes of antidepressants on the whole do not disrupt learning/memory. There have been a few reports of patients who have survived bilateral lesions of the pons with few lingering complications. Although these lesions essentially abolished REM sleep, the patients reportedly led normal lives. Recent functional imaging studies in humans have revealed patterns of brain activity in REM sleep that are consistent with dream processes but not with memory consolidation. We propose that the primary function of REM sleep is to provide periodic endogenous stimulation to the brain which serves to maintain requisite levels of central nervous system (CNS) activity throughout sleep. REM is the mechanism used by the brain to promote recovery from sleep. We believe that the cumulative evidence indicates that REM sleep serves no role in the processing or consolidation of memory. Key Words: antidepressant drugs; brain stem lesions; dreams; functional imaging; memory consolidation; REM deprivation; REM sleep; theta rhythm. (shrink)

I am, of course, aware that infanticide was accepted and practiced in ancient Greece and Rome, and is still practiced in places like India and China today; just as I am aware that slavery was accepted and practiced in ancient Greece and Rome , and is still practiced in some places today. But if philosophers, no matter how sophisticated, were to step forward today to argue that slavery is morally acceptable , I would call that madness.Of course, the ‘madness’ I (...) am referring to in condemning the advocacy of infanticide and slavery or their moral permissibility is moral madness. I am not making a clinical diagnosis of a psychiatric condition. I take it that this was obvious, but that Charles Camosy is nevertheless troubled that I would say such a thing. But I do say it. And at the risk of giving offense, I will say it again: advocating the moral permissibility of killing healthy newborn infants is moral madness; and it is scandalous, especially in a journal expressly directed not merely to philosophers but to physicians, nurses and other healthcare professionals—people whose attitudes shape decisions they make about the lives of real people, including real infants.Whatever errors of fact and judgment are made possible by the complexities of human development or a prenatal …. (shrink)

The writers respond to the commentary “Physician Burnout Calls for Legal Intervention,” by Sharona Hoffman, in the November‐December 2019 issue of the Hastings Center Report.

"Many in elite circles yield to the temptation to believe that anyone who disagrees with them is a bigot or a religious fundamentalist. Reason and science, they confidently believe, are on their side. With this book, I aim to expose the emptiness of that belief." --From the introductionAssaults on religious liberty and traditional morality are growing fiercer. Here, at last, is the counterattack.Showcasing the talents that have made him one of America's most acclaimed and influential thinkers, Robert P. George (...) explodes the myth that the secular elite represents the voice of reason. In fact, George shows, it is on the elite side of the cultural divide where the prevailing views frequently are nothing but articles of faith. Conscience and Its Enemies reveals the bankruptcy of these too often smugly held orthodoxies while presenting powerfully reasoned arguments for classical virtues.In defending what James Madison called the "sacred rights of conscience"--rights for which government shows frightening contempt--George grapples with today's most controversial issues: abortion and infanticide, same-sex marriage, genetic manipulation, euthanasia and assisted suicide, religion in politics, judicial activism, and more. His brilliantly argued essays rely not on theological claims or religious authority but on established scientific facts and a philosophical tradition that extends back to Plato and Aristotle.Conscience and Its Enemies elevates our national debates. It sets forth powerful arguments that secular liberals are unaccustomed to hearing--and that embattled defenders of traditional morality so often fail to marshal. It also lays out the principles and arguments for rebuilding a moral order. (shrink)

Celebrating science Content Type Journal Article Pages 1-3 DOI 10.1007/s11016-011-9545-1 Authors Robert P. Crease, Department of Philosophy, Stony Brook University, 213 Harriman Hall, Stony Brook, NY 11794-3750, USA Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

John Preston has claimed that we must understand Paul Feyerabend's later, post-1970, philosophy in terms of a disappointed Popperianism: that Feyerabend became a sceptical, relativistic, literal anarchist because of his perception of the failure of Popper's philosophy. I argue that this claim cannot be supported and trace the development of Feyerabend's philosophy in terms of a commitment to the central Popperian themes of criticism and critical explanatory progress. This commitment led Feyerabend to reject Popper's specific methodology in favour of a (...) pluralistic methodology, but the commitment to the central values of criticism and critical explanatory progress remained . Moreover, methodological pluralism does not imply scepticism, relativism, or literal anarchism. Feyerabend was not a disappointed Popperian, but, in many respects, a die-hard pluralistic Popperian. (shrink)

For some time now, commentators in and out of the scientific community have been expressing concern over the direction of scientific research. Cogent critics have labeled it excessively commercial, out of touch with its “pure,” public-spirited roots, and generally too much a creature of its entrepreneurial, self-interested times. In most if not all of this hand-wringing, the scientific community's growing reliance on intellectual property rights, especially patents, looms large. Indeed, for many the pursuit of patents is emblematic of just what (...) is rotten in the republic of science today. (shrink)